El premio Primetime Emmy a la mejor actriz invitada - Serie dramática (Primetime Emmy Award for Outstanding Guest Actress - Drama Series) es uno de los galardones Primetime Emmy.

• 1974 - Zohra Lampert, Kojak
• 1975 - no entregado
• 1976 - Fionnula Flanagan, Rich Man, Poor Man
• 1977 - Beulah Bondi, The Waltons
• 1978 - Rita Moreno, The Rockford Files
• 1979 - no entregado
• 1987 - Alfre Woodard, LA Law
• 1988 - Shirley Knight, thirtysomething
• 1989 - Kay Lenz, Midnight Caller
• 1990 - Viveca Lindfors, Life Goes On
• 1991 - Peggy McCay, The Trials of Rosie O'Neill
• 1992 - no entregado
• 1993 - Elaine Stritch, Law & Order
• 1994 - Faye Dunaway, Columbo: It's All in the Game
• 1995 - Shirley Knight, NYPD Blue
• 1996 - Amanda Plummer, The Outer Limits
• 1997 - Dianne Wiest, Road to Avonlea
• 1998 - Cloris Leachman, Promised Land
• 1999 - Debra Monk, NYPD Blue
• 2000 - Beah Richards, The Practice
• 2001 - Sally Field, ER
• 2002 - Patricia Clarkson, Six Feet Under
• 2003 - Alfre Woodard, The Practice
• 2004 - Sharon Stone, The Practice
• 2005 - Amanda Plummer, Law & Order: Special Victims Unit
• 2006 - Patricia Clarkson, Six Feet Under
• 2007 - Leslie Caron, Law & Order: Special Victims Unit
• 2008 - Cynthia Nixon, Law & Order: Special Victims Unit
• 2009 - Ellen Burstyn, Law & Order: Special Victims Unit
• 2010 - Ann-Margret, Law & Order: Special Victims Unit
• 2011 - Loretta Devine, Grey's Anatomy
• 2012 - Martha Plimpton, The Good Wife
• 2013 - Carrie Preston, The Good Wife
• 2014 - Allison Janney, Masters of Sex
• 2015 - Margo Martindale, The Americans
• 2016 - Margo Martindale, The Americans
• 2017 - Alexis Bledel, The Handmaid's Tale
• 2018 - Samira Wiley, 'The Handmaid's Tale

Este premio sólo fue presentado una vez, en 1977, a Olivia Cole por Roots.