DDIT3

Transcrito inducible por daño en el ADN 3
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	DDIT3 (HGNC: 2726) CEBPZ, CHOP, CHOP10, GADD153, MGC4154
Identificadores; externos	OMIM: 126337 ; EBI: DDIT3; GeneCards: Gen DDIT3; UniProt: DDIT3;
Locus	Cr. 12 q13.3
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
1649
P35638	n/a
NP_004074	n/a
	v; t; e;
	[editar datos en Wikidata]

El factor de transcripción DDIT3 (de sus siglas en inglés "DNA damage-inducible transcript 3"), también denominado CHOP o GADD153 es una proteína que, en humanos, es codificada por el gen ddit3.^[1]^[2] La proteína DDIT3 pertenece a la familia de las CEBPs y juega un importante papel en la célula regulando procesos relacionados con la proliferación y la diferenciación celular.^[3]

Interacciones

La proteína DDIT3 ha demostrado ser capaz de interaccionar con:

Véase también

Retículo endoplasmático

Referencias

↑ Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr, Barrett SF, Hickson ID, Fornace AJ Jr (Mar de 1991). «Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C». Mol Cell Biol 11 (2): 1009-16. PMC 359769. PMID 1990262.
↑ «Entrez Gene: DDIT3 DNA-damage-inducible transcript 3».
↑ Park JS, Luethy JD, Wang MG, Fargnoli J, Fornace AJ Jr, McBride OW, Holbrook NJ (Jul de 1992). «Isolation, characterization and chromosomal localization of the human GADD153 gene». Gene 116 (2): 259-267. PMID 1339368. doi:10.1210/en.2003-0868.
↑ Ubeda, Mariano; Habener Joel F (Oct. de 2003). «CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation». J. Biol. Chem. (United States) 278 (42): 40514-20. ISSN 0021-9258. PMID 12876286. doi:10.1074/jbc.M306404200.
↑ ^a ^b ^c Ubeda, M; Vallejo M, Habener J F (Nov. de 1999). «CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins». Mol. Cell. Biol. (UNITED STATES) 19 (11): 7589-99. ISSN 0270-7306. PMID 10523647.
↑ Cui, K; Coutts M, Stahl J, Sytkowski A J (Mar. de 2000). «Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis». J. Biol. Chem. (UNITED STATES) 275 (11): 7591-6. ISSN 0021-9258. PMID 10713066.
↑ Chen, B P; Wolfgang C D, Hai T (Mar. de 1996). «Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10». Mol. Cell. Biol. (UNITED STATES) 16 (3): 1157-68. ISSN 0270-7306. PMID 8622660.
↑ Hattori, Takayuki; Ohoka Nobumichi, Hayashi Hidetoshi, Onozaki Kikuo (Apr. de 2003). «C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform». FEBS Lett. (Netherlands) 541 (1-3): 33-9. ISSN 0014-5793. PMID 12706815.
↑ Fawcett, T W; Eastman H B, Martindale J L, Holbrook N J (Jun. de 1996). «Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress». J. Biol. Chem. (UNITED STATES) 271 (24): 14285-9. ISSN 0021-9258. PMID 8662954.

Enlaces externos

MeSH: DDIT3+protein,+human (en inglés)

Datos: Q17913616

[pmid1990262-1] Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr, Barrett SF, Hickson ID, Fornace AJ Jr (Mar de 1991). «Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C». Mol Cell Biol 11 (2): 1009-16. PMC 359769. PMID 1990262.

[entrez-2] «Entrez Gene: DDIT3 DNA-damage-inducible transcript 3».

[pmid1339368-3] Park JS, Luethy JD, Wang MG, Fargnoli J, Fornace AJ Jr, McBride OW, Holbrook NJ (Jul de 1992). «Isolation, characterization and chromosomal localization of the human GADD153 gene». Gene 116 (2): 259-267. PMID 1339368. doi:10.1210/en.2003-0868.

[pmid12876286-4] Ubeda, Mariano; Habener Joel F (Oct. de 2003). «CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation». J. Biol. Chem. (United States) 278 (42): 40514-20. ISSN 0021-9258. PMID 12876286. doi:10.1074/jbc.M306404200.

[pmid10523647-5] Ubeda, M; Vallejo M, Habener J F (Nov. de 1999). «CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins». Mol. Cell. Biol. (UNITED STATES) 19 (11): 7589-99. ISSN 0270-7306. PMID 10523647.

[pmid10713066-6] Cui, K; Coutts M, Stahl J, Sytkowski A J (Mar. de 2000). «Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis». J. Biol. Chem. (UNITED STATES) 275 (11): 7591-6. ISSN 0021-9258. PMID 10713066.

[pmid8622660-7] Chen, B P; Wolfgang C D, Hai T (Mar. de 1996). «Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10». Mol. Cell. Biol. (UNITED STATES) 16 (3): 1157-68. ISSN 0270-7306. PMID 8622660.

[pmid12706815-8] Hattori, Takayuki; Ohoka Nobumichi, Hayashi Hidetoshi, Onozaki Kikuo (Apr. de 2003). «C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform». FEBS Lett. (Netherlands) 541 (1-3): 33-9. ISSN 0014-5793. PMID 12706815.

[pmid8662954-9] Fawcett, T W; Eastman H B, Martindale J L, Holbrook N J (Jun. de 1996). «Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress». J. Biol. Chem. (UNITED STATES) 271 (24): 14285-9. ISSN 0021-9258. PMID 8662954.

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